Malegra 200 is a generic version of the medication Viagra, which contains the active ingredient sildenafil citrate. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, and it affects the smooth muscles in the penis by increasing blood flow to the area.

To understand how Malegra 200 affects the smooth muscles in the penis, let's break down the process:

Erection Process: The process of achieving an erection involves complex physiological mechanisms. When a man becomes sexually aroused, the brain sends signals to the nerves in the penis. These signals trigger the release of nitric oxide (NO) in the penile tissues.

Role of Nitric Oxide (NO): Nitric oxide is a chemical messenger that causes the relaxation of smooth muscle cells within the blood vessels of the penis. This relaxation allows the blood vessels to dilate, increasing blood flow to the spongy erectile tissues in the penis called the corpora cavernosa.

Role of PDE5: At the same time as the release of nitric oxide, an enzyme called phosphodiesterase type 5 (PDE5) is also released. PDE5 is responsible for breaking down cyclic guanosine monophosphate (cGMP), which is a substance that helps maintain the relaxation of smooth muscles in the penis during sexual arousal.

Effect of Sildenafil (Malegra 200): Sildenafil citrate in Malegra 200 works by inhibiting the action of PDE5. By doing so, it helps to prevent the breakdown of cGMP, which allows the smooth muscles in the penile blood vessels to stay relaxed for a more extended period. As a result, the blood flow to the penis increases, leading to a firmer and longer-lasting erection.