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Massachusetts Fishing Reports > Why does Vilitra 20 have a short half-life?
Why does Vilitra 20 have a short half-life?
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cliffordfosterr
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May 05, 2025
1:53 AM
Vilitra 20, which contains the active ingredient vardenafil, has a short half-life due to its pharmacokinetic properties, particularly its rapid metabolism in the liver. Vilitra 20mg is primarily metabolized by the cytochrome P450 enzyme system, especially CYP3A4, with some involvement of CYP3A5 and CYP2C9. Once absorbed, it reaches peak plasma concentrations quickly, within 30 to 120 minutes, and is eliminated relatively fast. Its terminal half-life is about 4 to 5 hours, which limits its duration of action. This short half-life contributes to a lower risk of prolonged side effects but also means its window of efficacy is narrower compared to drugs like tadalafil.


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