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Sep 26, 2025
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4?Bromophenol: A Versatile Intermediate
https://www.ketonepharma.com/product/4-bromophenol/
4?Bromophenol (a.k.a. p?bromophenol, CAS:?106?41?2) is an aromatic phenolic compound bearing a bromine atom at the para position relative to the hydroxyl group. It typically occurs as off?white or pale crystals with a phenolic smell. Physical properties include a melting point around 63–66?°C and a boiling point near 236–238?°C.
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ChemicalBook
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It is only sparingly soluble in water but dissolves readily in organic solvents like ethanol, ether, chloroform, and glacial acetic acid.
ChemicalBook
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ChemicalBook
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ChemicalBook
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Synthesis & Production Routes
A common laboratory route to 4?bromophenol is via electrophilic bromination of phenol under controlled conditions (often using bromine in a suitable solvent, cooled to low temperatures).
ChemicalBook
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ChemicalBook
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Some methods employ carbon disulfide as a solvent, slow addition of bromine, and purification via distillation or recrystallization.
ChemicalBook
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The yields are often in the 80–85?% range.
ChemicalBook
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Advanced synthetic variants (e.g. using N?bromosuccinimide) are also seen in literature.
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Ketone Pharma, a manufacturer in India specializing in fine chemicals and intermediates, lists 4?Bromophenol among its product portfolio, offering high purity grade (??99?%) material for use in organic synthesis, pharma, and specialty chemical markets.
ketonepharma
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Applications & Uses
Pharmaceutical & Agrochemical Intermediates: Because of its reactivity (due to the bromine substituent), 4?bromophenol acts as a building block in the synthesis of more complex molecules (APIs, intermediates, functionalized phenols).
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Chem-Impex
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Organic Synthesis: It participates in coupling reactions, substitution reactions, and as a scaffold for further functionalization.
ChemicalBook
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ChemicalBook
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Dyes & Pigments: It finds usage in the manufacture of specialty dyes, pigments, and phenolic resins.
Chem-Impex
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ChemicalBook
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Research & Lab Reagent: In academic and industrial labs, 4?bromophenol is used to explore reaction mechanisms, assay intermediates, and test synthetic methods.
Safety, Handling & Storage
4?Bromophenol is irritating to skin, eyes, and respiratory tract. It is classified under GHS hazard categories:
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
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Precautions include:
Use in a fume hood
Wear protective gloves, goggles, lab coat
Avoid inhalation or direct contact
Store in a cool, dry, well?ventilated place away from oxidizers, light, and heat sources
Dispose of waste following local chemical waste protocols
ChemicalBook
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ketonepharma
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According to the SDS from ChemicalBook India, acute oral toxicity (mouse) is LD?? ~ 523?mg/kg.
ChemicalBook
Choosing a Supplier & Purity Considerations
When sourcing 4?bromophenol (for example, from Ketone Pharma), key parameters to check are:
Purity / assay: Typically ??98–99?%
Impurities: Unreacted phenol, dibromo / polybromo side products
Moisture content & water content
Crystallinity & physical form (fine powder, crystals)
Certificate of Analysis (CoA), batch data, safety datasheets
Ketone Pharma’s product page indicates these quality attributes and provides the chemical, physical, and safety profile.
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