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Nov 17, 2025
11:01 PM
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Tazzle 20 mg Tazzle 20 mg contains tadalafil. Practo +2 1mg +2 It’s used for erectile dysfunction (ED), and sometimes for urinary symptoms of enlarged prostate (BPH). Practo Because tadalafil relaxes blood vessels, it can affect blood pressure. Apollo Pharmacy How Kidney Problems (Renal Impairment) Affect Tadalafil Increased Drug Exposure In people with impaired kidney function, exposure to tadalafil goes up. In clinical studies, the AUC (a measure of how much drug is in the body over time) doubled in people Tazzle 20mg mild or moderate renal impairment. PubMed +1 In people on hemodialysis or with very poor kidney function, exposure can be much higher. FDA Access Data Because of this, there is a risk of more side effects if the drug accumulates. European Medicines Agency (EMA) +1 Dose Adjustments Are Recommended According to regulatory guidance, in severe renal impairment, the maximum recommended dose is lower than 20 mg. For example, some sources suggest a maximum of 10 mg in patients with severe kidney problems. HPRA In very severe cases (e.g., very low creatinine clearance), once-a-day use of high-dose tadalafil is not recommended. HRES PDF A renal?drug?specific reference suggests caution and starting at lower doses in patients with low GFR. kidneydiseaseclinic.net Side?Effects Risk Because of higher exposure, side effects like back pain, muscle pain, or other typical tadalafil?related side effects may be more likely or more severe. PMC +1 There’s also a risk of hypotension (low blood pressure) because tadalafil dilates blood vessels, which might be more problematic in patients whose kidneys are not working well. ADCIRCA Dialysis Does Not Clear It Well In people on hemodialysis, dialysis does not significantly remove tadalafil. PubMed This means that once tadalafil is taken, it stays in the system for a longer time in those patients, increasing risk of accumulation.
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