Guest
Guest
Jan 09, 2026
2:28 AM
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Malegra DXT Plus is a dual-action medication that combines sildenafil citrate for erectile dysfunction (ED) and dapoxetine for premature ejaculation (PE). While highly effective, certain medications can interfere with its absorption, metabolism, or action, potentially reducing its effectiveness.
One major category is strong CYP3A4 inhibitors. Sildenafil is primarily metabolized by the liver enzyme CYP3A4, so drugs like ketoconazole, itraconazole, ritonavir, and some protease inhibitors can alter its metabolism. This may either increase side effects or reduce the intended effect depending on timing and dosage.
Certain antidepressants—especially selective serotonin reuptake inhibitors (SSRIs) other than dapoxetine—may interfere with dapoxetine’s action, potentially diminishing its effect on delaying ejaculation.
Other medications such as some blood pressure drugs (alpha-blockers) or nitrates can also affect the efficacy or safety of Malegra DXT Plus. These medications do not directly lower the effect but can increase the risk of side effects like low blood pressure, which may make sexual activity difficult or unsafe.
To maximize effectiveness and safety, men should consult their healthcare provider before using Malegra DXT Plus, especially if taking other prescription drugs, herbal supplements, or over-the-counter medications.
In summary, CYP3A4 inhibitors, certain antidepressants, and specific cardiovascular drugs may reduce or interfere with the action of Malegra DXT Plus, making professional guidance essential.
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