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Massachusetts Fishing Reports > Where does Fildena work in the body?
Where does Fildena  work in the body?
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Guest
Guest
Jan 21, 2026
1:58 AM
Fildena (Sildenafil) works primarily in the penis, but its effects involve the blood vessels and smooth muscles throughout the body. Here’s a clear step-by-step explanation of where and how it works: 1. The Target Organ: Penis During sexual stimulation, nerve signals release nitric oxide (NO) in the penis. NO activates cGMP, a molecule that relaxes smooth muscle in the corpora cavernosa (the two sponge-like chambers in the penis). Relaxed muscles allow blood to flow in, filling the penis and causing an erection. FILDENA job is to enhance and prolong this process. 2. How Fildena Works Sildenafil blocks the enzyme PDE-5 (phosphodiesterase type 5). PDE-5 normally breaks down cGMP. By inhibiting it, cGMP levels stay high, keeping the smooth muscles relaxed. Result: more blood enters the penis and erection is maintained longer. 3. Other Parts of the Body Sildenafil can also affect other tissues with PDE-5 enzymes, including: Lungs – can reduce pulmonary blood pressure slightly (used in pulmonary hypertension at different doses). Systemic blood vessels – may cause mild drop in blood pressure, sometimes leading to dizziness or flushing. Eyes – PDE-5 is present in the retina, which can occasionally cause blue/green vision tints. Key Points Fildena does not cause an automatic erection; sexual stimulation is required. Its primary site of action is the penile tissue, but other body systems can feel mild effects due to blood vessel relaxation. Most side effects (headache, flushing, dizziness) come from its systemic vascular effects, not direct action on the penis.
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Jan 21, 2026
5:07 AM
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