Guest
Guest
Feb 16, 2026
10:55 PM
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Duratia 60?mg contains tadalafil, a phosphodiesterase?5 (PDE5) inhibitor used to treat erectile dysfunction. Grapefruit and grapefruit juice can interfere with the metabolism of tadalafil in the liver because both affect the CYP3A4 enzyme, which is responsible for breaking down the drug. Here’s when Duratia 60?mg should not be taken with grapefruit: Within 24–48 hours of taking the dose – Grapefruit can increase tadalafil blood levels, which may intensify side effects such as: Headache Flushing Dizziness Nasal congestion Sudden drops in blood pressure If you regularly consume grapefruit or grapefruit juice – Even consistent daily intake can keep CYP3A4 partially inhibited, meaning every dose of Duratia 60 MG could be affected. When taking other medications metabolized by CYP3A4 – Grapefruit plus these drugs can compound interactions and side effects. Avoid grapefruit and grapefruit juice for at least 1–2 days before and after taking Duratia 60?mg, or as advised by your doctor, to ensure safe metabolism of the medication.
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