Guest
Guest
Aug 27, 2026
12:36 AM
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Vilitra contains vardenafil, and certain HIV medicines can interact with it. The main concern is with HIV protease inhibitors and other medicines that strongly inhibit the CYP3A4 enzyme, which normally helps break down vardenafil. These interactions can cause vardenafil levels to rise substantially, increasing the risk of side effects such as dizziness, low blood pressure, headache, and fainting.
For example, ritonavir can dramatically increase vardenafil exposure. Official prescribing information recommends that people taking ritonavir should not exceed 2.5 mg of vardenafil in a 72-hour period. Indinavir, saquinavir, and atazanavir can also require major dose restrictions.
Some HIV treatment regimens may contain cobicistat, another potent CYP3A4 inhibitor. Current prescribing information advises against using vardenafil with cobicistat because it can substantially increase vardenafil concentrations.
Therefore, do not take VILITRA with HIV medication without checking with your doctor or pharmacist first. The appropriate dose—or whether vardenafil should be used at all—depends on the exact HIV medicines in your regimen.
If you experience severe dizziness, fainting, chest pain, difficulty breathing, sudden vision or hearing changes, or an erection lasting more than four hours, seek urgent medical attention.
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